Image courtesy of Elkus Manfredi Architects

Boston’s life science boom could kickstart a South End development approved in 2013 that has yet to break ground.

The Druker Co. of Boston submitted new designs for an office-lab building at 80 East Berkeley St., where an office building project was previously approved and is currently occupied by a one-story repair garage.

The new design reduces the building size from 308,000 to 265,000 square feet, including a reduction in ground-floor space not devoted to offices and labs, and adds interior loading dock space for truck deliveries. The building height remains unchanged at 150 feet, although lab buildings’ need for bigger ceiling-to-ceiling heights to accommodate utilities reduces the number of floors from 11 to 10.

Designed by Elkus Manfredi Architects, the project also is updating its green building and climate resiliency strategies to reflect changes since it was originally proposed.

Developers now are targeting LEED v4 certification for the building’s core-and-shell construction, and the HVAC system will maximize electricity as its energy source, along with gas-fired boilers for peak heating periods. The ventilation system will be equipped with heat recovery systems to reduce energy use, and a 2,500-square-foot solar array is proposed on the southern side of the facade that screens mechanical systems.

The building would use 37 percent less energy than a typical code-compliant building, including an 87-percent decrease in natural gas usage, according to a notification form submitted to the Boston Planning & Development Agency.