Four separate leases were recently signed for an office building located at 400 Crown Colony Drive in Quincy.

Boston-based real estate advisory firm Richards Barry Joyce & Partners, LLC represented Quincy Office Investors Inc. in all four leases, according to a statement. The tenants in the leases are Philadelphia, Penn.-based Comcast Corp., Omaha, Neb.-based Mutual of Omaha, Chicago, Ill.-based CareerBuilder and UK-based Systagenix Wound Management.

Comcast signed a new lease for 14,679 square feet of office space on the fifth floor. The company was represented in the lease by CresaPartners.

CareerBuilder signed a new lease for 2,739 square feet of space on the third floor, and Mutual of Omaha signed a new lease for 3,928 square feet of office space on the building’s sixth floor. Grubb & Ellis represented both CareerBuilder and Mutual of Omaha in their leases.

Systagenix Wound Management’s lease was for 8,423 square feet of office space on the third floor. The location is now the company’s U.S. headquarters, according to a statement. They were represented in the transaction by Jones Lang LaSalle.

"400 Crown Colony’s amenities, ease of highway access and proximity to Downtown Boston have always made the building one of the top options in the area," said James Zilora, vice president of Quincy Office Investors. "We witnessed a sharp increase in the level of interest after the [recent] renovations were complete and the new access ramp was opened, and are very pleased to have attracted these industry-leading new tenants to the building."

The building currently has 22,300 square feet of space available.