Job losses continue to translate into occupancy declines across most of Greater Boston, according to Jones Lang LaSalle’s third quarter office statistics.

Third quarter net absorption was negative 410,931 square feet this quarter, although the Hub gained its first new office tower in five years with the completion of Two Financial Center. KPMG will be the first tenant to occupy the building with a lease for 43 percent of the 213,000-square-foot tower.

The Commonwealth of Massachusetts has relocated some offices from 1-2 South Station and moved four agencies into 138,000 square feet at 1000 Washington St. These transactions contributed to 93,194 square feet of positive net absorption this quarter.

Asking rents for premium tower space, nearly $70 per square foot in late 2007, were approximately $50 per square foot at the end of the quarter, according to the report.

Boston-area law firms continue to represent the largest demand sector in the downtown

Boston market and comprise seven of the largest requirements actively touring the market.

Bain Capital, Pioneer Investment Management and Monster.com are among the other large tenants in the market. Half of the large tenants currently pursuing relocation options have lease expirations beyond 2011, according to the report.

In Cambridge, the total vacancy rate ticked upward, mostly due to IBM’s pending lease expiration at 1 Rogers St. The Cambridge submarket, largely occupied by high technology, life science and pharmaceutical tenants has weathered this economic downtown relatively well compared to other submarkets in the region, but has experienced softer market fundamentals in recent quarters, the report shows.