Shire has leased 202,492 square feet at Two Ledgemont Center in Lexington for its new U.S. headquarters.

Transwestern | RBJ’s Robert Richards, president, and Brian Cohen, senior vice president, represented Shire in the lease for the entire five-floor building at 95 Hayden Ave.

The lease creates the largest suburban biotech campus in Greater Boston. Two Ledgemont Center is adjacent to Shire’s existing campus, which consists of more than 650,000 square feet of office and laboratory space at Lexington Technology Park. In total, Shire will occupy approximately 900,000 square feet in eight buildings in Lexington. In November 2014, Shire announced plans to establish Lexington as the company’s U.S. operational headquarters.

“After working closely with Shire’s management team to quantify the company’s space needs, we created a strategic plan that solved short- and mid-term needs and were able to expand the campus contiguously by sourcing Two Ledgemont Center,” Richards said in a statement.

As part of Shire’s occupancy in Two Ledgemont, Transwestern |│ RBJ negotiated interim office space at 235 Wyman St. for the company’s short-term growth plans.

The owner of Two Ledgemont, an affiliate of Hobbs Brook Management LLC, was represented by Chip Batchelder, managing director, Wyman Street Advisors.