Coldwell Banker Residential Brokerage New England is relocating its headquarters to a 54,034-square-foot office in Waltham.

Coldwell Banker and its affiliated companies NE Moves Mortgage LLC and NRT Insurance Agency Inc. will occupy the entire third floor at 52 Second Ave.

The companies are moving from 1601 Trapelo Road, also in Waltham, making this one of the largest relocations in the Route 128 West submarket during 2010, according to a statement.

"We are very excited to move our headquarters to this new location," said Rick Loughlin, president of Coldwell Banker Residential Brokerage New England. "The modern space has allowed us to expand our sales associate training facilities and include state-of-the-art amenities for our marketing, relocation and information technology teams. Overall this new space will enable our sales management, operations teams, and our mortgage and insurance partners to work side-by-side, which wasn’t possible in the previous location."

The Richards Barry Joyce & Partners team of Jon Varholak, partner, and Ron Friedman, senior vice president, represented the tenants in the lease. The sub-landlord of the space is National Grid, which was represented by Jones Lang LaSalle.

"Richards Barry Joyce & Partners provides in-depth real estate counsel for a wide range of companies, including those in high tech, professional services and finance," said Ron Friedman, senior vice president, RBJ&P. "Our key is to focus on the company’s business goals and determine how best to advance those through strategic and prudent real estate decisions."