The Boston Zoning Board of Appeals shot down a proposed Amazon last-mile distribution center in South Boston that recently drew opposition from the Boston Planning & Development Agency.

Core Development proposed converting a former Blue Cross Blue Shield warehouse into a last-mile distribution facility along with delivery vehicle parking on the 22-acre site, while demolishing two industrial buildings.

Attorney Joseph Hanley asked the zoning board of appeals to deny the application without prejudice at its meeting Tuesday. But Chair Christine Araujo asked for a straight denial, which was approved.

Developers are considering their next steps for the site, spokesman Thomas Palmer said.

The project drew a rebuke in September from BPDA directors who said it clashes with the agency’s Plan: Dot Ave. study, which recommends higher-density development including multifamily housing and offices to replace the  industrial uses between the MBTA’s Broadway and Andrew stations.

Core Development has said the distribution center would be the first phase of “On the Dot,” a longer-term mixed-use project spanning up to 8 million square feet.