Image courtesy of Core Investments

The latest development plans for a section of South Boston’s Dorchester Avenue once sought for an Amazon distribution center would begin with a 328,000-square-foot residential tower near the MBTA’s Andrew station.

Boston-based Core Investments is seeking to build nearly 3.8 million square feet of commercial and multifamily buildings in a 21-acre industrial section located on the western side of Dorchester Avenue. The developer is seeking approval under a planned development area master plan, allowing different phases to be built and financed under separate ownership.

“The development concept for the site is to construct new buildings with significant open space and public realm components as a vibrant mixed-use extension of the neighborhood,” developers said in a submission to the Boston Planning & Development Agency.

The project likely would be built in six phases, Core Investments said, starting at the southern end of the site. Groundbreaking would begin at 495 Dorchester Ave., a 328,000-square-foot, 196-foot-tall residential tower, in a block of four buildings that also includes three office-R&D buildings totaling over 1.3 million square feet and ranging from 198 to 215 feet in height.

The site currently includes a dozen commercial buildings and 223 surface parking spaces. The proposed master plan retains 2.9 acres of deed-restricted public open space, including a 1.5-acre park that would be created north of a realigned section of D Street.

Core Investments first submitted plans in 2021 for 1.7 million square feet of commercial and multifamily space in four towers located on Ellery Street and Dorchester Avenue.

Developers had sought approval for an Amazon last-mile distribution center on a portion of the site in 2020, but withdrew the application following a BPDA board vote opposing the project.