Photo courtesy of CBT Architects

A health care-focused REIT has made its second big-ticket commercial real estate investment in Greater Boston in four months, paying $320 million for a Waltham property redeveloped as tech and life science space.

Irvine, California-based Healthpeak Properties acquired the Post 200 Smith complex from Anchor Line Partners and Northwood Investors. The 430,000-square-foot complex is a former U.S. Postal Service office and warehouse now leased to tenants including Boston Dynamics, ElevateBio and Diciphera Pharmaceuticals.

CBT Architects designed the conversion of the one-story warehouse and three-story office building into creative workspace with outdoor terraces, a 50,000-square-foot mezzanine and amenities including a food hall, cafe and fitness center.

Anchor Line and Northwood investors acquired the 36-acre property in 2015 for $39.5 million.

In December, Healthpeak acquired another successful redevelopment in Cambridge’s Alewife section, paying $332.5 million for the 224,305-square-foot Alewife Research Center. The Davis Cos. of Boston and Invesco partnered on the redevelopment and expansion of the 35 Cambridgepark Drive office building into life science space which is now 100-percent leased to five biotech and pharmaceutical firms.