Wells Fargo has leased 150,000 square feet at 125 High St. in the Financial District and will begin relocating 775 employees from three locations in downtown Boston and Back Bay late next year.

It’s the second major office tenant to make a long-term commitment to the 1.5-million-square-foot tower in the past month. Publisher Houghton Mifflin Harcourt recently signed a 16-year lease for 162,000 square feet on the fifth through eighth floors with plans to relocate its headquarters from 222 East Berkeley St. in Back Bay in early 2017.

The 14-year lease for the 11th through 15th floors enables Wells Fargo to consolidate space from three buildings in the downtown and Back Bay beginning in late 2016, spokeswoman Krista Van Tassel said. More than 775 employees will move from 1 Boston Place, 101 Federal St. and 200 Berkeley St.

“We’re a large company and have multiple lines of business in the region,” Van Tassel said. “This is an opportunity to enhance our collaboration.”

The regional commercial bank, home mortgage and commercial real estate units based at 101 Federal St. will be the first to move in late 2016, along with the community lending and investment group located at 1 Boston Place. The rest of the move will be phased over a three-year period. Wells Fargo Advisors will remain at 2 International Place.

The company limited its search to the Financial District because of its strong public transit access, VanTassel said.

Owned by New York developer Tishman Speyer, 125 High St. is a three-building complex overlooking the Rose Fitzgerald Kennedy Greenway. The building would have been headed for a 376,000-square-foot spike in vacancy after PwC moves to the new 101 Seaport office tower in South Boston later this year. All but 64,000 square feet is now spoken for.

Cushman & Wakefield’s William Anderson and William Motley represented Wells Fargo in the transaction.